increased intestinal adenoma incidence_Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>,Lrig1<tm1.1(cre/ERT2)Rjc>/Lrig1<tm1.1(cre/ERT2)Rjc>

http://metadb.riken.jp/0002404I129129P2OlaHsdC57BL6Lgr5tm1creERT2CleLgr5Lrig1tm11creERT2RjcLrig1tm11creERT2RjcLgr5tm1creERT2CleLgr5Lrig1tm11creERT2Rjc

increased intestinal adenoma incidence_Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>,Lrig1<tm1.1(cre/ERT2)Rjc>/Lrig1<tm1.1(cre/ERT2)Rjc>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• leucine rich repeat containing G protein coupled receptor 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:1341817
• leucine-rich repeats and immunoglobulin-like domains 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:107935

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>,Lrig1<tm1.1(cre/ERT2)Rjc>/Lrig1<tm1.1(cre/ERT2)Rjc>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lgr5<tm1(cre/ERT2)Cle>|Lgr5<+>|Lrig1<tm1.1(cre/ERT2)Rjc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased intestinal adenoma incidence
  http://purl.obolibrary.org/obo/MP_0002404

文献

http://purl.org/net/cito/citesAsAuthority

• Anne E. Powell, et.al., The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor., Cell, 2012, 149
  http://rdf.ncbi.nlm.nih.gov/pubmed/22464327