increased intestinal adenoma incidence_Bmi1<tm1Brn>/Bmi1<tm1Brn>,Apc<tm2Cip>/Apc<+>,Cdkn2a<tm1Cjs>/Cdkn2a<tm1Cjs>,Tg(Vil-cre)20Syr/0

http://metadb.riken.jp/0002404I129P2OlaHsd129X1SvJC57BL6DBA2Bmi1tm1BrnBmi1tm1BrnApctm2CipApcCdkn2atm1CjsCdkn2atm1CjsTgVilcre20Syr0Cdkn2atm1CjsBmi1tm1BrnTgVilcre20SyrApcApctm2Cip

increased intestinal adenoma incidence_Bmi1<tm1Brn>/Bmi1<tm1Brn>,Apc<tm2Cip>/Apc<+>,Cdkn2a<tm1Cjs>/Cdkn2a<tm1Cjs>,Tg(Vil-cre)20Syr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Bmi1 polycomb ring finger oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88174
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• adenomatosis polyposis coli
  http://metadb.riken.jp/db/mgi_rdf/MGI:88039
• transgene insertion 20, Sylvie Robine
  http://metadb.riken.jp/db/mgi_rdf/MGI:3053809

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Bmi1<tm1Brn>/Bmi1<tm1Brn>,Apc<tm2Cip>/Apc<+>,Cdkn2a<tm1Cjs>/Cdkn2a<tm1Cjs>,Tg(Vil-cre)20Syr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn2a<tm1Cjs>|Bmi1<tm1Brn>|Tg(Vil-cre)20Syr|Apc<+>|Apc<tm2Cip>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased intestinal adenoma incidence
  http://purl.obolibrary.org/obo/MP_0002404

文献

http://purl.org/net/cito/citesAsAuthority

• M A. Maynard, et.al., Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer., Oncogene, 2014, 33
  http://rdf.ncbi.nlm.nih.gov/pubmed/23955081