increased intestinal adenoma incidence_Apc<Min>/Apc<+>,Gpa33<tm1(GNAS)Wtsi>/Gpa33<+>,Hprt<tm1(CMV-cre)Brd>/?

http://metadb.riken.jp/0002404I129S7SvEvBrdC57BL6JApcMinApcGpa33tm1GNASWtsiGpa33Hprttm1CMVcreBrdGpa33ApcMinApcGpa33tm1GNASWtsiHprttm1CMVcreBrd

increased intestinal adenoma incidence_Apc<Min>/Apc<+>,Gpa33<tm1(GNAS)Wtsi>/Gpa33<+>,Hprt<tm1(CMV-cre)Brd>/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• hypoxanthine guanine phosphoribosyl transferase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96217
• adenomatosis polyposis coli
  http://metadb.riken.jp/db/mgi_rdf/MGI:88039
• glycoprotein A33 (transmembrane)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1891703

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Apc<Min>/Apc<+>,Gpa33<tm1(GNAS)Wtsi>/Gpa33<+>,Hprt<tm1(CMV-cre)Brd>/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gpa33<+>|Apc<Min>|Apc<+>|Gpa33<tm1(GNAS)Wtsi>|Hprt<tm1(CMV-cre)Brd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased intestinal adenoma incidence
  http://purl.obolibrary.org/obo/MP_0002404

文献

http://purl.org/net/cito/citesAsAuthority

• C H. Wilson, et.al., The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways., Oncogene, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20531296