increased susceptibility to bacterial infection_Il12rb2<Ifnm-d>/Il12rb2<Ifnm-d>,Tlr4<lps-del>/Tlr4<lps-del>

http://metadb.riken.jp/0002412C57BL10ScCrIl12rb2IfnmdIl12rb2IfnmdTlr4lpsdelTlr4lpsdelTlr4lpsdelIl12rb2Ifnmd

increased susceptibility to bacterial infection_Il12rb2<Ifnm-d>/Il12rb2<Ifnm-d>,Tlr4<lps-del>/Tlr4<lps-del>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• toll-like receptor 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:96824
• interleukin 12 receptor, beta 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1270861

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Il12rb2<Ifnm-d>/Il12rb2<Ifnm-d>,Tlr4<lps-del>/Tlr4<lps-del>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tlr4<lps-del>|Il12rb2<Ifnm-d>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• C57BL/10ScCr

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased susceptibility to bacterial infection
  http://purl.obolibrary.org/obo/MP_0002412

文献

http://purl.org/net/cito/citesAsAuthority

• P. Kropf, et.al., Infection of C57BL/10ScCr and C57BL/10ScNCr mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication., Journal of leukocyte biology, 2004, 76
  http://rdf.ncbi.nlm.nih.gov/pubmed/15039466
• A. Poltorak, et.al., A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice., Journal of immunology (Baltimore, Md. : 1950), 2001, 167
  http://rdf.ncbi.nlm.nih.gov/pubmed/11489994