increased susceptibility to viral infection_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp)37Jcol/?

http://metadb.riken.jp/0002418I129Sv129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnp37JcolTgPrnp37JcolPrnptm1Cwe

increased susceptibility to viral infection_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp)37Jcol/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• prion protein
  http://metadb.riken.jp/db/mgi_rdf/MGI:97769
• transgene insertion 37, John Collinge
  http://metadb.riken.jp/db/mgi_rdf/MGI:3761837

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp)37Jcol/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Prnp)37Jcol|Prnp<tm1Cwe>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased susceptibility to viral infection
  http://purl.obolibrary.org/obo/MP_0002418

文献

http://purl.org/net/cito/citesAsAuthority

• Giovanna R. Mallucci, et.al., Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice., Neuron, 2007, 53
  http://rdf.ncbi.nlm.nih.gov/pubmed/17270731
• G R. Mallucci, et.al., Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration., The EMBO journal, 2002, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/11823413