abnormal B cell physiology_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm2(Cd74*)Awai>/Gt(ROSA)26Sor<+>,Il10<tm1Roer>/Il10<tm1Roer>

http://metadb.riken.jp/0002459I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm2Cd74AwaiGtROSA26SorIl10tm1RoerIl10tm1RoerCd19tm1creCgnGtROSA26Sortm2Cd74AwaiCd19GtROSA26SorIl10tm1Roer

abnormal B cell physiology_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm2(Cd74*)Awai>/Gt(ROSA)26Sor<+>,Il10<tm1Roer>/Il10<tm1Roer>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• interleukin 10
  http://metadb.riken.jp/db/mgi_rdf/MGI:96537
• CD19 antigen
  http://metadb.riken.jp/db/mgi_rdf/MGI:88319

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm2(Cd74*)Awai>/Gt(ROSA)26Sor<+>,Il10<tm1Roer>/Il10<tm1Roer>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cd19<tm1(cre)Cgn>|Gt(ROSA)26Sor<tm2(Cd74*)Awai>|Cd19<+>|Gt(ROSA)26Sor<+>|Il10<tm1Roer>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal B cell physiology
  http://purl.obolibrary.org/obo/MP_0002459

文献

http://purl.org/net/cito/citesAsAuthority

• Friederike. Frommer, et.al., Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion., Journal of immunology (Baltimore, Md. : 1950), 2008, 181
  http://rdf.ncbi.nlm.nih.gov/pubmed/18832734