abnormal neutrophil physiology_Pten<tm1Hwu>/Pten<tm1Hwu>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

http://metadb.riken.jp/0002463I129P2OlaHsd129S4SvJaePtentm1HwuPtentm1HwuLyz2tm1creIfoLyz2Ptentm1HwuLyz2Lyz2tm1creIfo

abnormal neutrophil physiology_Pten<tm1Hwu>/Pten<tm1Hwu>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• lysozyme 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96897
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm1Hwu>/Pten<tm1Hwu>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Hwu>|Lyz2<+>|Lyz2<tm1(cre)Ifo>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal neutrophil physiology
  http://purl.obolibrary.org/obo/MP_0002463

文献

http://purl.org/net/cito/citesAsAuthority

• Yitang. Li, et.al., Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia., Blood, 2009, 113
  http://rdf.ncbi.nlm.nih.gov/pubmed/19286998
• Daocheng. Zhu, et.al., Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death., Proceedings of the National Academy of Sciences of the United States of America, 2006, 103
  http://rdf.ncbi.nlm.nih.gov/pubmed/16988010
• Kulandayan K. Subramanian, et.al., Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions., Blood, 2007, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/17202315