increased IgM level_Igh-J<tm1(Ighel)Cys>/Igh-J<tm1(Ighel)Cys>,Myd88<tm1Aki>/Myd88<tm1Aki>,Igkj1<tm1(IgkHyHEL10)Mnz>/0

http://metadb.riken.jp/0002494I129P2OlaHsdIghJtm1IghelCysIghJtm1IghelCysMyd88tm1AkiMyd88tm1AkiIgkj1tm1IgkHyHEL10Mnz0IghJtm1IghelCysIgkj1tm1IgkHyHEL10MnzMyd88tm1Aki

increased IgM level_Igh-J<tm1(Ighel)Cys>/Igh-J<tm1(Ighel)Cys>,Myd88<tm1Aki>/Myd88<tm1Aki>,Igkj1<tm1(IgkHyHEL10)Mnz>/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• myeloid differentiation primary response gene 88
  http://metadb.riken.jp/db/mgi_rdf/MGI:108005
• immunoglobulin heavy chain, joining region
  http://metadb.riken.jp/db/mgi_rdf/MGI:96461
• immunoglobulin kappa joining 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1316689

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Igh-J<tm1(Ighel)Cys>/Igh-J<tm1(Ighel)Cys>,Myd88<tm1Aki>/Myd88<tm1Aki>,Igkj1<tm1(IgkHyHEL10)Mnz>/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Igh-J<tm1(Ighel)Cys>|Igkj1<tm1(IgkHyHEL10)Mnz>|Myd88<tm1Aki>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased IgM level
  http://purl.obolibrary.org/obo/MP_0002494

文献

http://purl.org/net/cito/citesAsAuthority

• Karlee. Silver, et.al., TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire., European journal of immunology, 2006, 36
  http://rdf.ncbi.nlm.nih.gov/pubmed/16703567