abnormal ameloblast morphology_Hras<tm1Jaf>/Hras<+>,Tg(CAG-cre)13Miya/0

http://metadb.riken.jp/0002650I129S6SvEvTacBlackSwissC57BL6Hrastm1JafHrasTgCAGcre13Miya0TgCAGcre13MiyaHrastm1JafHras

abnormal ameloblast morphology_Hras<tm1Jaf>/Hras<+>,Tg(CAG-cre)13Miya/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Harvey rat sarcoma virus oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:96224
• transgene insertion 13, Jun-ichi Miyazaki
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176594

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hras<tm1Jaf>/Hras<+>,Tg(CAG-cre)13Miya/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(CAG-cre)13Miya|Hras<tm1Jaf>|Hras<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * Black Swiss * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal ameloblast morphology
  http://purl.obolibrary.org/obo/MP_0002650

文献

http://purl.org/net/cito/citesAsAuthority

• Alice F. Goodwin, et.al., Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation., Human molecular genetics, 2014, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/24057668
• Xu. Chen, et.al., Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19416908