increased circulating testosterone level_Cyp19a1<tm1Esi>/Cyp19a1<tm1Esi>

http://metadb.riken.jp/0002781I129S6SvEvTacC57BL6Cyp19a1tm1EsiCyp19a1tm1EsiCyp19a1tm1Esi

increased circulating testosterone level_Cyp19a1<tm1Esi>/Cyp19a1<tm1Esi>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cytochrome P450, family 19, subfamily a, polypeptide 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88587

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cyp19a1<tm1Esi>/Cyp19a1<tm1Esi>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cyp19a1<tm1Esi>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased circulating testosterone level
  http://purl.obolibrary.org/obo/MP_0002781

文献

http://purl.org/net/cito/citesAsAuthority

• K M. Robertson, et.al., Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene., Proceedings of the National Academy of Sciences of the United States of America, 1999, 96
  http://rdf.ncbi.nlm.nih.gov/pubmed/10393934
• S J. McPherson, et.al., Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland., Endocrinology, 2001, 142
  http://rdf.ncbi.nlm.nih.gov/pubmed/11356695
• C R. Fisher, et.al., Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene., Proceedings of the National Academy of Sciences of the United States of America, 1998, 95
  http://rdf.ncbi.nlm.nih.gov/pubmed/9618522