impaired skin barrier function_Prss8<Gt(IST10122F12)Tigm>/Prss8<Gt(IST10122F12)Tigm>

http://metadb.riken.jp/0002796I129S6SvEvTacBlackSwissC57BL6JC57BL6NPrss8GtIST10122F12TigmPrss8GtIST10122F12TigmPrss8GtIST10122F12Tigm

impaired skin barrier function_Prss8<Gt(IST10122F12)Tigm>/Prss8<Gt(IST10122F12)Tigm>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protease, serine 8 (prostasin)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1923810

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Prss8<Gt(IST10122F12)Tigm>/Prss8<Gt(IST10122F12)Tigm>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Prss8<Gt(IST10122F12)Tigm>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• impaired skin barrier function
  http://purl.obolibrary.org/obo/MP_0002796

文献

http://purl.org/net/cito/citesAsAuthority

• Roman. Szabo, et.al., Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation., PLoS genetics, 2012, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/22952456