microcytic anemia_Hba<tm1(HBA)Tow>/Hba<tm1(HBA)Tow>,Hbb<tm2(HBG1,HBB*)Tow>/Hbb<tm3(HBG1,HBB)Tow>,Slc12a4<Rbc10>/Slc12a4<Rbc10>

http://metadb.riken.jp/0002810I129BALBcC57BL6JHbatm1HBATowHbatm1HBATowHbbtm2HBG1HBBTowHbbtm3HBG1HBBTowSlc12a4Rbc10Slc12a4Rbc10Hbbtm2HBG1HBBTowHbbtm3HBG1HBBTowSlc12a4Rbc10Hbatm1HBATow

microcytic anemia_Hba<tm1(HBA)Tow>/Hba<tm1(HBA)Tow>,Hbb<tm2(HBG1,HBB*)Tow>/Hbb<tm3(HBG1,HBB)Tow>,Slc12a4<Rbc10>/Slc12a4<Rbc10>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• hemoglobin beta chain complex
  http://metadb.riken.jp/db/mgi_rdf/MGI:96020
• hemoglobin alpha chain complex
  http://metadb.riken.jp/db/mgi_rdf/MGI:96014
• solute carrier family 12, member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1309465

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hba<tm1(HBA)Tow>/Hba<tm1(HBA)Tow>,Hbb<tm2(HBG1,HBB*)Tow>/Hbb<tm3(HBG1,HBB)Tow>,Slc12a4<Rbc10>/Slc12a4<Rbc10>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Hbb<tm2(HBG1,HBB*)Tow>|Hbb<tm3(HBG1,HBB)Tow>|Slc12a4<Rbc10>|Hba<tm1(HBA)Tow>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * BALB/c * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• microcytic anemia
  http://purl.obolibrary.org/obo/MP_0002810

文献

http://purl.org/net/cito/citesAsAuthority

• Fiona C. Brown, et.al., Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model., Blood, 2015, 126
  http://rdf.ncbi.nlm.nih.gov/pubmed/26450986