abnormal bone mineralization_Cyp27b1<tm1Star>/Cyp27b1<tm1Star>

http://metadb.riken.jp/0002896I129S1Sv129X1SvJCyp27b1tm1StarCyp27b1tm1StarCyp27b1tm1Star

abnormal bone mineralization_Cyp27b1<tm1Star>/Cyp27b1<tm1Star>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cytochrome P450, family 27, subfamily b, polypeptide 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1098274

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cyp27b1<tm1Star>/Cyp27b1<tm1Star>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cyp27b1<tm1Star>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal bone mineralization
  http://purl.obolibrary.org/obo/MP_0002896

文献

http://purl.org/net/cito/citesAsAuthority

• O. Dardenne, et.al., Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)., Bone, 2003, 32
  http://rdf.ncbi.nlm.nih.gov/pubmed/12689675
• Olivier. Dardenne, et.al., Rescue of the pseudo-vitamin D deficiency rickets phenotype of CYP27B1-deficient mice by treatment with 1,25-dihydroxyvitamin D3: biochemical, histomorphometric, and biomechanical analyses., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2003, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/12674324