decreased paired-pulse facilitation_Psen1<tm4.1Shn>/Psen1<+>,Psen2<tm1Haa>/Psen2<tm1Haa>

http://metadb.riken.jp/0002920I129C57BL6C57BL6JPsen1tm41ShnPsen1Psen2tm1HaaPsen2tm1HaaPsen2tm1HaaPsen1Psen1tm41Shn

decreased paired-pulse facilitation_Psen1<tm4.1Shn>/Psen1<+>,Psen2<tm1Haa>/Psen2<tm1Haa>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• presenilin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1202717
• presenilin 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109284

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Psen1<tm4.1Shn>/Psen1<+>,Psen2<tm1Haa>/Psen2<tm1Haa>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Psen2<tm1Haa>|Psen1<+>|Psen1<tm4.1Shn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased paired-pulse facilitation
  http://purl.obolibrary.org/obo/MP_0002920

文献

http://purl.org/net/cito/citesAsAuthority

• Dan. Xia, et.al., Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease., Neuron, 2015, 85
  http://rdf.ncbi.nlm.nih.gov/pubmed/25741723