increased hemangioma incidence_Ctnnb1<tm2Kem>/Ctnnb1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0

http://metadb.riken.jp/0002947I129C57BL6FVBNICRSJLCtnnb1tm2KemCtnnb1GtROSA26Sortm1rtTAEGFPNagyGtROSA26SorTgCol2a1cre1Bhr0TgtetOVegfa90Ala0GtROSA26Sortm1rtTAEGFPNagyTgCol2a1cre1BhrTgtetOVegfa90AlaCtnnb1Ctnnb1tm2KemGtROSA26Sor

increased hemangioma incidence_Ctnnb1<tm2Kem>/Ctnnb1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276
• transgene insertion 1, Richard R Behringer
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176069
• transgene insertion 90, Ann L Akeson
  http://metadb.riken.jp/db/mgi_rdf/MGI:3586337

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctnnb1<tm2Kem>/Ctnnb1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>|Tg(Col2a1-cre)1Bhr|Tg(tetO-Vegfa)90Ala|Ctnnb1<+>|Ctnnb1<tm2Kem>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * FVB/N * ICR * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hemangioma incidence
  http://purl.obolibrary.org/obo/MP_0002947

文献

http://purl.org/net/cito/citesAsAuthority

• Christa. Maes, et.al., Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones., The EMBO journal, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20010698