increased intestinal adenocarcinoma incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Prom1<tm1(cre/ERT2)Gilb>/Prom1<+>

http://metadb.riken.jp/0002957I129S6SvEvTac129X1SvJCtnnb1tm1MmtCtnnb1GtROSA26Sortm1EYFPCosGtROSA26SorProm1tm1creERT2GilbProm1Prom1tm1creERT2GilbGtROSA26Sortm1EYFPCosCtnnb1Ctnnb1tm1MmtProm1GtROSA26Sor

increased intestinal adenocarcinoma incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Prom1<tm1(cre/ERT2)Gilb>/Prom1<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• prominin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1100886
• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctnnb1<tm1Mmt>/Ctnnb1<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Prom1<tm1(cre/ERT2)Gilb>/Prom1<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Prom1<tm1(cre/ERT2)Gilb>|Gt(ROSA)26Sor<tm1(EYFP)Cos>|Ctnnb1<+>|Ctnnb1<tm1Mmt>|Prom1<+>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased intestinal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0002957

文献

http://purl.org/net/cito/citesAsAuthority

• Liqin. Zhu, et.al., Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation., Nature, 2009, 457
  http://rdf.ncbi.nlm.nih.gov/pubmed/19092805