decreased urine osmolality_Cldn10<tm1.1Dmu>/Cldn10<tm1.1Dmu>,Tg(Cdh16-cre)91Igr/0

http://metadb.riken.jp/0002988IC57BL6ICRSJLCldn10tm11DmuCldn10tm11DmuTgCdh16cre91Igr0Cldn10tm11DmuTgCdh16cre91Igr

decreased urine osmolality_Cldn10<tm1.1Dmu>/Cldn10<tm1.1Dmu>,Tg(Cdh16-cre)91Igr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 91, Peter Igarashi
  http://metadb.riken.jp/db/mgi_rdf/MGI:2665302
• claudin 10
  http://metadb.riken.jp/db/mgi_rdf/MGI:1913101

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cldn10<tm1.1Dmu>/Cldn10<tm1.1Dmu>,Tg(Cdh16-cre)91Igr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cldn10<tm1.1Dmu>|Tg(Cdh16-cre)91Igr

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * ICR * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased urine osmolality
  http://purl.obolibrary.org/obo/MP_0002988

文献

http://purl.org/net/cito/citesAsAuthority

• Tilman. Breiderhoff, et.al., Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/22891322