abnormal cytokine secretion_Npc1<m1N>/Npc1<m1N>,Tlr4<tm1Aki>/Tlr4<tm1Aki>

http://metadb.riken.jp/0003009I129P2OlaHsdBALBcNpc1m1NNpc1m1NTlr4tm1AkiTlr4tm1AkiTlr4tm1AkiNpc1m1N

abnormal cytokine secretion_Npc1<m1N>/Npc1<m1N>,Tlr4<tm1Aki>/Tlr4<tm1Aki>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• toll-like receptor 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:96824
• Niemann-Pick type C1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1097712

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Npc1<m1N>/Npc1<m1N>,Tlr4<tm1Aki>/Tlr4<tm1Aki>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tlr4<tm1Aki>|Npc1<m1N>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * BALB/c

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal cytokine secretion
  http://purl.obolibrary.org/obo/MP_0003009

文献

http://purl.org/net/cito/citesAsAuthority

• Michitaka. Suzuki, et.al., Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/17314284