decreased insulin secretion_Pdx1<tm2Cvw>/Pdx1<+>,Slc2a4<tm1Mch>/Slc2a4<+>

http://metadb.riken.jp/0003059I129SvBlackSwissC57BL6SJLPdx1tm2CvwPdx1Slc2a4tm1MchSlc2a4Slc2a4tm1MchPdx1tm2CvwSlc2a4Pdx1

decreased insulin secretion_Pdx1<tm2Cvw>/Pdx1<+>,Slc2a4<tm1Mch>/Slc2a4<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• solute carrier family 2 (facilitated glucose transporter), member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:95758
• pancreatic and duodenal homeobox 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:102851

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pdx1<tm2Cvw>/Pdx1<+>,Slc2a4<tm1Mch>/Slc2a4<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Slc2a4<tm1Mch>|Pdx1<tm2Cvw>|Slc2a4<+>|Pdx1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * Black Swiss * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased insulin secretion
  http://purl.obolibrary.org/obo/MP_0003059

文献

http://purl.org/net/cito/citesAsAuthority

• Marcela. Brissova, et.al., Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis., American journal of physiology. Endocrinology and metabolism, 2005, 288
  http://rdf.ncbi.nlm.nih.gov/pubmed/15562255