increased vascular permeability_Sphk1<tm1.1Cgh>/Sphk1<tm2Cgh>,Sphk2<tm1.1Cgh>/Sphk2<tm1.1Cgh>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0003070I129S4SvJaeC57BL6CBASphk1tm11CghSphk1tm2CghSphk2tm11CghSphk2tm11CghTgMx1cre1Cgn0Sphk2tm11CghTgMx1cre1CgnSphk1tm2CghSphk1tm11Cgh

increased vascular permeability_Sphk1<tm1.1Cgh>/Sphk1<tm2Cgh>,Sphk2<tm1.1Cgh>/Sphk2<tm1.1Cgh>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• sphingosine kinase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1861380
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• sphingosine kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1316649

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Sphk1<tm1.1Cgh>/Sphk1<tm2Cgh>,Sphk2<tm1.1Cgh>/Sphk2<tm1.1Cgh>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Sphk2<tm1.1Cgh>|Tg(Mx1-cre)1Cgn|Sphk1<tm2Cgh>|Sphk1<tm1.1Cgh>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased vascular permeability
  http://purl.obolibrary.org/obo/MP_0003070

文献

http://purl.org/net/cito/citesAsAuthority

• Brett H. Herzog, et.al., Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2., Nature, 2013, 502
  http://rdf.ncbi.nlm.nih.gov/pubmed/23995678