abnormal cell migration_Gt(ROSA)26Sor<tm1(rtTA)Awu>/Gt(ROSA)26Sor<+>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(tetO-cre)LC1Bjd/0

http://metadb.riken.jp/0003091I129P2OlaHsd129S1Sv129S4SvJae129X1SvJGtROSA26Sortm1rtTAAwuGtROSA26SorHif1atm3RsjoHif1atm3RsjoTgtetOcreLC1Bjd0Hif1atm3RsjoTgtetOcreLC1BjdGtROSA26Sortm1rtTAAwuGtROSA26Sor

abnormal cell migration_Gt(ROSA)26Sor<tm1(rtTA)Awu>/Gt(ROSA)26Sor<+>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(tetO-cre)LC1Bjd/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion LC1, Hermann Bujard
  http://metadb.riken.jp/db/mgi_rdf/MGI:2671943
• hypoxia inducible factor 1, alpha subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:106918
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(rtTA)Awu>/Gt(ROSA)26Sor<+>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(tetO-cre)LC1Bjd/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Hif1a<tm3Rsjo>|Tg(tetO-cre)LC1Bjd|Gt(ROSA)26Sor<tm1(rtTA)Awu>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal cell migration
  http://purl.obolibrary.org/obo/MP_0003091

文献

http://purl.org/net/cito/citesAsAuthority

• Debra F. Higgins, et.al., Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition., The Journal of clinical investigation, 2007, 117
  http://rdf.ncbi.nlm.nih.gov/pubmed/18037992