abnormal cell nucleus morphology_Lmna<tm1Lgf>/Lmna<+>

http://metadb.riken.jp/0003111I129P2OlaHsdC57BL6Lmnatm1LgfLmnaLmnatm1LgfLmna

abnormal cell nucleus morphology_Lmna<tm1Lgf>/Lmna<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• lamin A
  http://metadb.riken.jp/db/mgi_rdf/MGI:96794

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lmna<tm1Lgf>/Lmna<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lmna<tm1Lgf>|Lmna<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal cell nucleus morphology
  http://purl.obolibrary.org/obo/MP_0003111

文献

http://purl.org/net/cito/citesAsAuthority

• Shao H. Yang, et.al., Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation., Proceedings of the National Academy of Sciences of the United States of America, 2005, 102
  http://rdf.ncbi.nlm.nih.gov/pubmed/16014412
• Brandon S J. Davies, et.al., Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome., Journal of lipid research, 2009, 50
  http://rdf.ncbi.nlm.nih.gov/pubmed/18757838
• Shao H. Yang, et.al., Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated., The Journal of clinical investigation, 2008, 118
  http://rdf.ncbi.nlm.nih.gov/pubmed/18769635