abnormal telomere length_Terc<tm1Rdp>/Terc<tm1Rdp>

http://metadb.riken.jp/0003155I129SvC57BL6JSJLTerctm1RdpTerctm1RdpTerctm1Rdp

abnormal telomere length_Terc<tm1Rdp>/Terc<tm1Rdp>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• telomerase RNA component
  http://metadb.riken.jp/db/mgi_rdf/MGI:109558

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Terc<tm1Rdp>/Terc<tm1Rdp>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Terc<tm1Rdp>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal telomere length
  http://purl.obolibrary.org/obo/MP_0003155

文献

http://purl.org/net/cito/citesAsAuthority

• Sonia. Franco, et.al., Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres., Cancer research, 2002, 62
  http://rdf.ncbi.nlm.nih.gov/pubmed/11809709
• Annarosa. Leri, et.al., Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation., The EMBO journal, 2003, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/12505991
• Christine M. Khoo, et.al., Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse., Proceedings of the National Academy of Sciences of the United States of America, 2007, 104
  http://rdf.ncbi.nlm.nih.gov/pubmed/17360455
• M A. Blasco, et.al., Telomere shortening and tumor formation by mouse cells lacking telomerase RNA., Cell, 1997, 91
  http://rdf.ncbi.nlm.nih.gov/pubmed/9335332
• Lin. Liu, et.al., Irregular telomeres impair meiotic synapsis and recombination in mice., Proceedings of the National Academy of Sciences of the United States of America, 2004, 101
  http://rdf.ncbi.nlm.nih.gov/pubmed/15084742
• E. Herrera, et.al., Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube., The EMBO journal, 1999, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/10064584
• E. Herrera, et.al., Impaired germinal center reaction in mice with short telomeres., The EMBO journal, 2000, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/10654945
• María Luisa. Cayuela, et.al., The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression., EMBO reports, 2005, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/15731767