neuron degeneration_Cx3cr1<tm1Litt>/Cx3cr1<+>,Psen1<tm1Mpm>/Psen1<tm1Mpm>,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0

http://metadb.riken.jp/0003224I129P2OlaHsd129S1Sv129X1SvJC57BL6CBACx3cr1tm1LittCx3cr1Psen1tm1MpmPsen1tm1MpmTgAPPSwetauP301L1Lfa0TgThy1YFPHJrs0TgAPPSwetauP301L1LfaCx3cr1Cx3cr1tm1LittPsen1tm1MpmTgThy1YFPHJrs

neuron degeneration_Cx3cr1<tm1Litt>/Cx3cr1<+>,Psen1<tm1Mpm>/Psen1<tm1Mpm>,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion H, Joshua R Sanes
  http://metadb.riken.jp/db/mgi_rdf/MGI:3497950
• presenilin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1202717
• transgene insertion 1, Frank M LaFerla
  http://metadb.riken.jp/db/mgi_rdf/MGI:2684637
• chemokine (C-X3-C motif) receptor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1333815

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cx3cr1<tm1Litt>/Cx3cr1<+>,Psen1<tm1Mpm>/Psen1<tm1Mpm>,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(APPSwe,tauP301L)1Lfa|Cx3cr1<+>|Cx3cr1<tm1Litt>|Psen1<tm1Mpm>|Tg(Thy1-YFP)HJrs

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• neuron degeneration
  http://purl.obolibrary.org/obo/MP_0003224

文献

http://purl.org/net/cito/citesAsAuthority

• Martin. Fuhrmann, et.al., Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease., Nature neuroscience, 2010, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/20305648