loss of hippocampal neurons_C3<tm1Crr>/C3<tm1Crr>,Tg(PDGFB-APPSwInd)20Lms/?

http://metadb.riken.jp/0003240I129S4SvJaeC57BL6C3tm1CrrC3tm1CrrTgPDGFBAPPSwInd20LmsC3tm1CrrTgPDGFBAPPSwInd20Lms

loss of hippocampal neurons_C3<tm1Crr>/C3<tm1Crr>,Tg(PDGFB-APPSwInd)20Lms/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 20, Lennart Mucke
  http://metadb.riken.jp/db/mgi_rdf/MGI:3057146
• complement component 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:88227

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• C3<tm1Crr>/C3<tm1Crr>,Tg(PDGFB-APPSwInd)20Lms/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• C3<tm1Crr>|Tg(PDGFB-APPSwInd)20Lms

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• loss of hippocampal neurons
  http://purl.obolibrary.org/obo/MP_0003240

文献

http://purl.org/net/cito/citesAsAuthority

• Marcel. Maier, et.al., Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/18562603