abnormal dopaminergic neuron morphology_Gt(ROSA)26Sor<tm1(LRRK2*R1441C)Djmo>/Gt(ROSA)26Sor<tm1(LRRK2*R1441C)Djmo>,Tg(Slc6a3-icre)1Fto/0

http://metadb.riken.jp/0003243I129C57BL6JFVBNGtROSA26Sortm1LRRK2R1441CDjmoGtROSA26Sortm1LRRK2R1441CDjmoTgSlc6a3icre1Fto0GtROSA26Sortm1LRRK2R1441CDjmoTgSlc6a3icre1Fto

abnormal dopaminergic neuron morphology_Gt(ROSA)26Sor<tm1(LRRK2*R1441C)Djmo>/Gt(ROSA)26Sor<tm1(LRRK2*R1441C)Djmo>,Tg(Slc6a3-icre)1Fto/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, Francois Tronche
  http://metadb.riken.jp/db/mgi_rdf/MGI:3852082

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(LRRK2*R1441C)Djmo>/Gt(ROSA)26Sor<tm1(LRRK2*R1441C)Djmo>,Tg(Slc6a3-icre)1Fto/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1(LRRK2*R1441C)Djmo>|Tg(Slc6a3-icre)1Fto

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal dopaminergic neuron morphology
  http://purl.obolibrary.org/obo/MP_0003243

文献

http://purl.org/net/cito/citesAsAuthority

• Elpida. Tsika, et.al., Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration., Neurobiology of disease, 2014, 71
  http://rdf.ncbi.nlm.nih.gov/pubmed/25174890