amyloid beta deposits_Psen1<tm1Lpr>/Psen1<tm1Lpr>,Tg(Thy1-APP<SL>)28Lpr/0

http://metadb.riken.jp/0003329I129C57BL6CBAPsen1tm1LprPsen1tm1LprTgThy1APPSL28Lpr0Psen1tm1LprTgThy1APPSL28Lpr

amyloid beta deposits_Psen1<tm1Lpr>/Psen1<tm1Lpr>,Tg(Thy1-APP<SL>)28Lpr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 28, Laurent Pradier
  http://metadb.riken.jp/db/mgi_rdf/MGI:3510602
• presenilin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1202717

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Psen1<tm1Lpr>/Psen1<tm1Lpr>,Tg(Thy1-APP<SL>)28Lpr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Psen1<tm1Lpr>|Tg(Thy1-APP<SL>)28Lpr

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• amyloid beta deposits
  http://purl.obolibrary.org/obo/MP_0003329

文献

http://purl.org/net/cito/citesAsAuthority

• Marie-Caroline. Cotel, et.al., Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice., Brain research, 2008, 1222
  http://rdf.ncbi.nlm.nih.gov/pubmed/18585693
• Oliver. Wirths, et.al., Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease., Experimental gerontology, 2006, 41
  http://rdf.ncbi.nlm.nih.gov/pubmed/16307858
• Oliver. Wirths, et.al., Age-dependent axonal degeneration in an Alzheimer mouse model., Neurobiology of aging, 2007, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/16963164
• Ditte Zerlang. Christensen, et.al., Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice., Acta neuropathologica, 2008, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/18974993