amyloid beta deposits_Apoe<tm1Unc>/Apoe<tm1Unc>,Tg(APPV717F)109Ili/0,Tg(GFAP-APOE_i4)#Hol/0

http://metadb.riken.jp/0003329I129P2OlaHsdC57BL6CBAApoetm1UncApoetm1UncTgAPPV717F109Ili0TgGFAPAPOEi4Hol0TgGFAPAPOEi4HolTgAPPV717F109IliApoetm1Unc

amyloid beta deposits_Apoe<tm1Unc>/Apoe<tm1Unc>,Tg(APPV717F)109Ili/0,Tg(GFAP-APOE_i4)#Hol/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• apolipoprotein E
  http://metadb.riken.jp/db/mgi_rdf/MGI:88057
• transgene insertion, David M Holtzman
  http://metadb.riken.jp/db/mgi_rdf/MGI:3784189
• transgene insertion 109, Ivan Lieberburg
  http://metadb.riken.jp/db/mgi_rdf/MGI:2152038

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Apoe<tm1Unc>/Apoe<tm1Unc>,Tg(APPV717F)109Ili/0,Tg(GFAP-APOE_i4)#Hol/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(GFAP-APOE_i4)#Hol|Tg(APPV717F)109Ili|Apoe<tm1Unc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• amyloid beta deposits
  http://purl.obolibrary.org/obo/MP_0003329

文献

http://purl.org/net/cito/citesAsAuthority

• Anne M. Fagan, et.al., Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease., Neurobiology of disease, 2002, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/11950276
• Richard E. Hartman, et.al., Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/12451108