amyloid beta deposits_Tg(APP695)3Dbo/0,Tg(PSEN1)5Dbo/0

http://metadb.riken.jp/0003329IC3HHeJC57BL6JTgAPP6953Dbo0TgPSEN15Dbo0TgPSEN15DboTgAPP6953Dbo

amyloid beta deposits_Tg(APP695)3Dbo/0,Tg(PSEN1)5Dbo/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 3, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448606
• transgene insertion 5, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448609

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(APP695)3Dbo/0,Tg(PSEN1)5Dbo/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(PSEN1)5Dbo|Tg(APP695)3Dbo

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C3H/HeJ * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• amyloid beta deposits
  http://purl.obolibrary.org/obo/MP_0003329

文献

http://purl.org/net/cito/citesAsAuthority

• D R. Borchelt, et.al., Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins., Neuron, 1997, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/9354339
• http://rdf.ncbi.nlm.nih.gov/pubmed/11959394
• Joanna L. Jankowsky, et.al., Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase., Human molecular genetics, 2004, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/14645205