amyloid beta deposits_Tg(APP695)3Dbo/0,Tg(PSEN1dE9)S9Dbo/0

http://metadb.riken.jp/0003329IC3HHeJC57BL6JTgAPP6953Dbo0TgPSEN1dE9S9Dbo0TgAPP6953DboTgPSEN1dE9S9Dbo

amyloid beta deposits_Tg(APP695)3Dbo/0,Tg(PSEN1dE9)S9Dbo/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 3, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448606
• transgene insertion S9, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:3618598

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(APP695)3Dbo/0,Tg(PSEN1dE9)S9Dbo/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(APP695)3Dbo|Tg(PSEN1dE9)S9Dbo

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C3H/HeJ * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• amyloid beta deposits
  http://purl.obolibrary.org/obo/MP_0003329

文献

http://purl.org/net/cito/citesAsAuthority

• Joanna L. Jankowsky, et.al., Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase., Human molecular genetics, 2004, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/14645205
• Alena. Savonenko, et.al., Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities., Neurobiology of disease, 2005, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/15755686