amyloid beta deposits_Tg(Hmgcr-PSEN1*M146L)#Lpr/0,Tg(Thy1-APP<SL>)28Lpr/0

http://metadb.riken.jp/0003329IC57BL6CBATgHmgcrPSEN1M146LLpr0TgThy1APPSL28Lpr0TgHmgcrPSEN1M146LLprTgThy1APPSL28Lpr

amyloid beta deposits_Tg(Hmgcr-PSEN1*M146L)#Lpr/0,Tg(Thy1-APP<SL>)28Lpr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 28, Laurent Pradier
  http://metadb.riken.jp/db/mgi_rdf/MGI:3510602
• transgene insertion, Laurent Pradier
  http://metadb.riken.jp/db/mgi_rdf/MGI:5003457

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(Hmgcr-PSEN1*M146L)#Lpr/0,Tg(Thy1-APP<SL>)28Lpr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Hmgcr-PSEN1*M146L)#Lpr|Tg(Thy1-APP<SL>)28Lpr

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• amyloid beta deposits
  http://purl.obolibrary.org/obo/MP_0003329

文献

http://purl.org/net/cito/citesAsAuthority

• Bart P F. Rutten, et.al., Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice., The American journal of pathology, 2005, 167
  http://rdf.ncbi.nlm.nih.gov/pubmed/15972962
• Véronique. Blanchard, et.al., Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice., Experimental neurology, 2003, 184
  http://rdf.ncbi.nlm.nih.gov/pubmed/14637096
• Oliver. Wirths, et.al., Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease., Experimental gerontology, 2006, 41
  http://rdf.ncbi.nlm.nih.gov/pubmed/16307858