increased hepatocellular carcinoma incidence_Bhlha15<tm2(Kras)Skz>/Bhlha15<+>,Trp53<tm1Tyj>/Trp53<+>

http://metadb.riken.jp/0003331I129S2SvPas129S6SvEvTacC57BL6Bhlha15tm2KrasSkzBhlha15Trp53tm1TyjTrp53Bhlha15tm2KrasSkzBhlha15Trp53tm1TyjTrp53

increased hepatocellular carcinoma incidence_Bhlha15<tm2(Kras)Skz>/Bhlha15<+>,Trp53<tm1Tyj>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• basic helix-loop-helix family, member a15
  http://metadb.riken.jp/db/mgi_rdf/MGI:891976
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Bhlha15<tm2(Kras)Skz>/Bhlha15<+>,Trp53<tm1Tyj>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Bhlha15<tm2(Kras)Skz>|Bhlha15<+>|Trp53<tm1Tyj>|Trp53<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hepatocellular carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0003331

文献

http://purl.org/net/cito/citesAsAuthority

• David A. Tuveson, et.al., Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma., Cancer research, 2006, 66
  http://rdf.ncbi.nlm.nih.gov/pubmed/16397237