increased hepatocellular carcinoma incidence_Gt(ROSA)26Sor<tm2(sb11)Njen>/Gt(ROSA)26Sor<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Alb-cre)21Mgn/0,TgTn(sb-T2/Onc)68Dla/0

http://metadb.riken.jp/0003331I129S4SvJaeC57BL6DBA2FVBNGtROSA26Sortm2sb11NjenGtROSA26SorTrp53tm3TyjTrp53TgAlbcre21Mgn0TgTnsbT2Onc68Dla0Trp53tm3TyjTgAlbcre21MgnGtROSA26SorGtROSA26Sortm2sb11NjenTrp53TgTnsbT2Onc68Dla

increased hepatocellular carcinoma incidence_Gt(ROSA)26Sor<tm2(sb11)Njen>/Gt(ROSA)26Sor<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Alb-cre)21Mgn/0,TgTn(sb-T2/Onc)68Dla/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 21, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176226
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgenic transposon concatemer 68, David A Largaespada
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612983
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm2(sb11)Njen>/Gt(ROSA)26Sor<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Alb-cre)21Mgn/0,TgTn(sb-T2/Onc)68Dla/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm3Tyj>|Tg(Alb-cre)21Mgn|Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm2(sb11)Njen>|Trp53<+>|TgTn(sb-T2/Onc)68Dla

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hepatocellular carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0003331

文献

http://purl.org/net/cito/citesAsAuthority

• Vincent W. Keng, et.al., A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma., Nature biotechnology, 2009, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/19234449