decreased pancreatic beta cell number_Arx<tm1Gldn>/Arx<tm1Gldn>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0

http://metadb.riken.jp/0003339I129BlackSwissC57BL6CBAJSJLArxtm1GldnArxtm1GldnNkx22tm21SussNkx22tm21SussTgIns2cre23Herr0Arxtm1GldnTgIns2cre23HerrNkx22tm21Suss

decreased pancreatic beta cell number_Arx<tm1Gldn>/Arx<tm1Gldn>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• aristaless related homeobox
  http://metadb.riken.jp/db/mgi_rdf/MGI:1097716
• transgene insertion 23, Pedro Luis Herrera
  http://metadb.riken.jp/db/mgi_rdf/MGI:4431238
• NK2 homeobox 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97347

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Arx<tm1Gldn>/Arx<tm1Gldn>,Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Tg(Ins2-cre)23Herr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Arx<tm1Gldn>|Tg(Ins2-cre)23Herr|Nkx2-2<tm2.1Suss>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * Black Swiss * C57BL/6 * CBA/J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased pancreatic beta cell number
  http://purl.obolibrary.org/obo/MP_0003339

文献

http://purl.org/net/cito/citesAsAuthority

• James B. Papizan, et.al., Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming., Genes & development, 2011, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/22056672