increased thyroid adenoma incidence_Gt(ROSA)26Sor<tm1(H1/tetO-RNAi:Pdpk1)Mrl>/Gt(ROSA)26Sor<+>,Pten<tm1.1Hwu>/Pten<+>

http://metadb.riken.jp/0003496I129S4SvJaeC57BL6NTacGtROSA26Sortm1H1tetORNAiPdpk1MrlGtROSA26SorPtentm11HwuPtenPtenGtROSA26Sortm1H1tetORNAiPdpk1MrlGtROSA26SorPtentm11Hwu

increased thyroid adenoma incidence_Gt(ROSA)26Sor<tm1(H1/tetO-RNAi:Pdpk1)Mrl>/Gt(ROSA)26Sor<+>,Pten<tm1.1Hwu>/Pten<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(H1/tetO-RNAi:Pdpk1)Mrl>/Gt(ROSA)26Sor<+>,Pten<tm1.1Hwu>/Pten<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<+>|Gt(ROSA)26Sor<tm1(H1/tetO-RNAi:Pdpk1)Mrl>|Gt(ROSA)26Sor<+>|Pten<tm1.1Hwu>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6NTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased thyroid adenoma incidence
  http://purl.obolibrary.org/obo/MP_0003496

文献

http://purl.org/net/cito/citesAsAuthority

• Katharine. Ellwood-Yen, et.al., PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models., Cancer research, 2011, 71
  http://rdf.ncbi.nlm.nih.gov/pubmed/21493594