increased pancreatic beta cell number_Cdkn1b<tm1Kin>/Cdkn1b<tm1Kin>,Irs2<tm1Mfw>/Irs2<tm1Mfw>

http://metadb.riken.jp/0003645I129S1Sv129X1SvJC57BL6JCdkn1btm1KinCdkn1btm1KinIrs2tm1MfwIrs2tm1MfwCdkn1btm1KinIrs2tm1Mfw

increased pancreatic beta cell number_Cdkn1b<tm1Kin>/Cdkn1b<tm1Kin>,Irs2<tm1Mfw>/Irs2<tm1Mfw>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cyclin-dependent kinase inhibitor 1B
  http://metadb.riken.jp/db/mgi_rdf/MGI:104565
• insulin receptor substrate 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109334

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn1b<tm1Kin>/Cdkn1b<tm1Kin>,Irs2<tm1Mfw>/Irs2<tm1Mfw>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn1b<tm1Kin>|Irs2<tm1Mfw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic beta cell number
  http://purl.obolibrary.org/obo/MP_0003645

文献

http://purl.org/net/cito/citesAsAuthority

• Tohru. Uchida, et.al., Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice., Nature medicine, 2005, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/15685168