increased osteosarcoma incidence_Brca2<tm1Kamc>/Brca2<tm1Kamc>,Trp53<tm1Tyj>/Trp53<+>

http://metadb.riken.jp/0003789I129P2OlaHsd129S2SvPasBALBcC57BL6Brca2tm1KamcBrca2tm1KamcTrp53tm1TyjTrp53Brca2tm1KamcTrp53Trp53tm1Tyj

increased osteosarcoma incidence_Brca2<tm1Kamc>/Brca2<tm1Kamc>,Trp53<tm1Tyj>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• breast cancer 2, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:109337

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca2<tm1Kamc>/Brca2<tm1Kamc>,Trp53<tm1Tyj>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Brca2<tm1Kamc>|Trp53<+>|Trp53<tm1Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased osteosarcoma incidence
  http://purl.obolibrary.org/obo/MP_0003789

文献

http://purl.org/net/cito/citesAsAuthority

• Kimberly A. McAllister, et.al., Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation., Toxicologic pathology, 2006, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/16546942