increased osteosarcoma incidence_Ptch1<tm1Yy>/Ptch1<+>,Trp53<tm1Brd>/Trp53<+>,Tg(BGLAP-cre)1Clem/0

http://metadb.riken.jp/0003789I129S7SvEvBrdC57BL6FVBNJPtch1tm1YyPtch1Trp53tm1BrdTrp53TgBGLAPcre1Clem0Trp53Ptch1Ptch1tm1YyTgBGLAPcre1ClemTrp53tm1Brd

increased osteosarcoma incidence_Ptch1<tm1Yy>/Ptch1<+>,Trp53<tm1Brd>/Trp53<+>,Tg(BGLAP-cre)1Clem/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 1, Thomas L Clemens
  http://metadb.riken.jp/db/mgi_rdf/MGI:2450260
• patched 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:105373

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptch1<tm1Yy>/Ptch1<+>,Trp53<tm1Brd>/Trp53<+>,Tg(BGLAP-cre)1Clem/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<+>|Ptch1<+>|Ptch1<tm1Yy>|Tg(BGLAP-cre)1Clem|Trp53<tm1Brd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased osteosarcoma incidence
  http://purl.obolibrary.org/obo/MP_0003789

文献

http://purl.org/net/cito/citesAsAuthority

• L H. Chan, et.al., Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression., Oncogene, 2014, 33
  http://rdf.ncbi.nlm.nih.gov/pubmed/24141783