increased atrioventricular cushion size_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Tek-cre)12Flv/0

http://metadb.riken.jp/0003808I129S6SvEvTacC3HC57BL6Ptpn11tm6BgnPtpn11TgTekcre12Flv0Ptpn11Ptpn11tm6BgnTgTekcre12Flv

increased atrioventricular cushion size_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Tek-cre)12Flv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein tyrosine phosphatase, non-receptor type 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:99511
• transgene insertion 12, Richard A Flavell
  http://metadb.riken.jp/db/mgi_rdf/MGI:2136409

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Tek-cre)12Flv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptpn11<+>|Ptpn11<tm6Bgn>|Tg(Tek-cre)12Flv

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C3H * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased atrioventricular cushion size
  http://purl.obolibrary.org/obo/MP_0003808

文献

http://purl.org/net/cito/citesAsAuthority

• Toshiyuki. Araki, et.al., Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19251646