tonic-clonic seizures_Scn1a<tm2.1Wac>/Scn1a<+>,Tg(I12b-cre)1Jlr/0

http://metadb.riken.jp/0003997IC57BL6JCD1Scn1atm21WacScn1aTgI12bcre1Jlr0Scn1aTgI12bcre1JlrScn1atm21Wac

tonic-clonic seizures_Scn1a<tm2.1Wac>/Scn1a<+>,Tg(I12b-cre)1Jlr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• sodium channel, voltage-gated, type I, alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:98246
• transgene insertion 1, John LR Rubenstein
  http://metadb.riken.jp/db/mgi_rdf/MGI:3833427

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Scn1a<tm2.1Wac>/Scn1a<+>,Tg(I12b-cre)1Jlr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Scn1a<+>|Tg(I12b-cre)1Jlr|Scn1a<tm2.1Wac>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6J * CD-1

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• tonic-clonic seizures
  http://purl.obolibrary.org/obo/MP_0003997

文献

http://purl.org/net/cito/citesAsAuthority

• Christine S. Cheah, et.al., Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/22908258