impaired passive avoidance behavior_Tlr2<tm1Kir>/Tlr2<tm1Kir>,Tg(APP695)3Dbo/?,Tg(PSEN1)5Dbo/?

http://metadb.riken.jp/0004000I129C3HHeJC57BL6Tlr2tm1KirTlr2tm1KirTgAPP6953DboTgPSEN15DboTgAPP6953DboTgPSEN15DboTlr2tm1Kir

impaired passive avoidance behavior_Tlr2<tm1Kir>/Tlr2<tm1Kir>,Tg(APP695)3Dbo/?,Tg(PSEN1)5Dbo/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 5, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448609
• toll-like receptor 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346060
• transgene insertion 3, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448606

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tlr2<tm1Kir>/Tlr2<tm1Kir>,Tg(APP695)3Dbo/?,Tg(PSEN1)5Dbo/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(APP695)3Dbo|Tg(PSEN1)5Dbo|Tlr2<tm1Kir>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C3H/HeJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• impaired passive avoidance behavior
  http://purl.obolibrary.org/obo/MP_0004000

文献

http://purl.org/net/cito/citesAsAuthority

• Karine L. Richard, et.al., Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/18509040