decreased bone mass_Lrp5<tm1Grw>/Lrp5<tm1Grw>

http://metadb.riken.jp/0004016I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw

decreased bone mass_Lrp5<tm1Grw>/Lrp5<tm1Grw>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• low density lipoprotein receptor-related protein 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:1278315

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lrp5<tm1Grw>/Lrp5<tm1Grw>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lrp5<tm1Grw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased bone mass
  http://purl.obolibrary.org/obo/MP_0004016

文献

http://purl.org/net/cito/citesAsAuthority

• Rajendra. Kedlaya, et.al., Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome., Science translational medicine, 2013, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/24225945
• Philippe. Clément-Lacroix, et.al., Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice., Proceedings of the National Academy of Sciences of the United States of America, 2005, 102
  http://rdf.ncbi.nlm.nih.gov/pubmed/16293698