abnormal cell cycle checkpoint function_Trp53<tm1Brd>/Trp53<tm1Brd>

http://metadb.riken.jp/0004045I129S7SvEvBrdTrp53tm1BrdTrp53tm1BrdTrp53tm1Brd

abnormal cell cycle checkpoint function_Trp53<tm1Brd>/Trp53<tm1Brd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Trp53<tm1Brd>/Trp53<tm1Brd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal cell cycle checkpoint function
  http://purl.obolibrary.org/obo/MP_0004045

文献

http://purl.org/net/cito/citesAsAuthority

• Melissa T. Jack, et.al., Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response., Proceedings of the National Academy of Sciences of the United States of America, 2002, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/12097646
• Atsushi. Hirao, et.al., Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner., Molecular and cellular biology, 2002, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/12192050