increased squamous cell carcinoma incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tgfbr1<tm1.1Karl>/Tgfbr1<tm1.1Karl>,Tg(KRT14-cre/ERT)20Efu/0

http://metadb.riken.jp/0004207I129129S4SvJaeC57BL6CD1FVBNPtentm1HwuPtentm1HwuTgfbr1tm11KarlTgfbr1tm11KarlTgKRT14creERT20Efu0TgKRT14creERT20EfuTgfbr1tm11KarlPtentm1Hwu

increased squamous cell carcinoma incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tgfbr1<tm1.1Karl>/Tgfbr1<tm1.1Karl>,Tg(KRT14-cre/ERT)20Efu/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 20, Elaine Fuchs
  http://metadb.riken.jp/db/mgi_rdf/MGI:2446592
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• transforming growth factor, beta receptor I
  http://metadb.riken.jp/db/mgi_rdf/MGI:98728

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm1Hwu>/Pten<tm1Hwu>,Tgfbr1<tm1.1Karl>/Tgfbr1<tm1.1Karl>,Tg(KRT14-cre/ERT)20Efu/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(KRT14-cre/ERT)20Efu|Tgfbr1<tm1.1Karl>|Pten<tm1Hwu>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased squamous cell carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0004207

文献

http://purl.org/net/cito/citesAsAuthority

• Zhi-Jun. Sun, et.al., Inhibition of mTOR reduces anal carcinogenesis in transgenic mouse model., PloS one, 2013, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/24124460
• Zhi-Jun. Sun, et.al., Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model., Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/22859719