cerebral amyloid angiopathy_Lrp1<tm2Her>/Lrp1<tm2Her>,Tg(APP695)3Dbo/0,Tg(PSEN1)5Dbo/0,Tg(Tagln-cre)1Her/0

http://metadb.riken.jp/0004254I129S7SvEvBrdC3HHeJC57BL6C57BL6JSJLLrp1tm2HerLrp1tm2HerTgAPP6953Dbo0TgPSEN15Dbo0TgTaglncre1Her0TgAPP6953DboTgPSEN15DboTgTaglncre1HerLrp1tm2Her

cerebral amyloid angiopathy_Lrp1<tm2Her>/Lrp1<tm2Her>,Tg(APP695)3Dbo/0,Tg(PSEN1)5Dbo/0,Tg(Tagln-cre)1Her/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• low density lipoprotein receptor-related protein 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:96828
• transgene insertion 5, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448609
• transgene insertion 3, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448606
• transgene insertion 1, Joachim Herz
  http://metadb.riken.jp/db/mgi_rdf/MGI:2450259

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lrp1<tm2Her>/Lrp1<tm2Her>,Tg(APP695)3Dbo/0,Tg(PSEN1)5Dbo/0,Tg(Tagln-cre)1Her/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(APP695)3Dbo|Tg(PSEN1)5Dbo|Tg(Tagln-cre)1Her|Lrp1<tm2Her>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• cerebral amyloid angiopathy
  http://purl.obolibrary.org/obo/MP_0004254

文献

http://purl.org/net/cito/citesAsAuthority

• Takahisa. Kanekiyo, et.al., LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, 32
  http://rdf.ncbi.nlm.nih.gov/pubmed/23152628