decreased response of heart to induced stress_Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,Myl2<tm1(cre)Krc>/Myl2<+>

http://metadb.riken.jp/0004486I129P2OlaHsd129S4SvJae129S7SvEvBrdC57BLGna11tm1SoffGna11tm1SoffGnaqtm2SoffGnaqtm2SoffMyl2tm1creKrcMyl2Gnaqtm2SoffMyl2Gna11tm1SoffMyl2tm1creKrc

decreased response of heart to induced stress_Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,Myl2<tm1(cre)Krc>/Myl2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• guanine nucleotide binding protein, alpha 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:95766
• guanine nucleotide binding protein, alpha q polypeptide
  http://metadb.riken.jp/db/mgi_rdf/MGI:95776
• myosin, light polypeptide 2, regulatory, cardiac, slow
  http://metadb.riken.jp/db/mgi_rdf/MGI:97272

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,Myl2<tm1(cre)Krc>/Myl2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gnaq<tm2Soff>|Myl2<+>|Gna11<tm1Soff>|Myl2<tm1(cre)Krc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased response of heart to induced stress
  http://purl.obolibrary.org/obo/MP_0004486

文献

http://purl.org/net/cito/citesAsAuthority

• N. Wettschureck, et.al., Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes., Nature medicine, 2001, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/11689889