increased susceptibility to experimental autoimmune encephalomyelitis_Pdcd1<tm1Hon>/Pdcd1<tm1Hon>,Vsir<tm1Lex>/Vsir<tm1Lex>,Tg(Tcra2D2,Tcrb2D2)1Kuch/0

http://metadb.riken.jp/0004799I129S2SvPas129S5SvEvBrdC57BL6Pdcd1tm1HonPdcd1tm1HonVsirtm1LexVsirtm1LexTgTcra2D2Tcrb2D21Kuch0Pdcd1tm1HonTgTcra2D2Tcrb2D21KuchVsirtm1Lex

increased susceptibility to experimental autoimmune encephalomyelitis_Pdcd1<tm1Hon>/Pdcd1<tm1Hon>,Vsir<tm1Lex>/Vsir<tm1Lex>,Tg(Tcra2D2,Tcrb2D2)1Kuch/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Vijay Kuchroo
  http://metadb.riken.jp/db/mgi_rdf/MGI:3700835
• V-set immunoregulatory receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:1921298
• programmed cell death 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:104879

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pdcd1<tm1Hon>/Pdcd1<tm1Hon>,Vsir<tm1Lex>/Vsir<tm1Lex>,Tg(Tcra2D2,Tcrb2D2)1Kuch/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pdcd1<tm1Hon>|Tg(Tcra2D2,Tcrb2D2)1Kuch|Vsir<tm1Lex>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased susceptibility to experimental autoimmune encephalomyelitis
  http://purl.obolibrary.org/obo/MP_0004799

文献

http://purl.org/net/cito/citesAsAuthority

• Jun. Liu, et.al., Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses., Proceedings of the National Academy of Sciences of the United States of America, 2015, 112
  http://rdf.ncbi.nlm.nih.gov/pubmed/25964334