decreased susceptibility to autoimmune diabetes_Prf1<tm1Clrk>/Prf1<tm1Clrk>,Tg(INS-Il10)#Sar/0

http://metadb.riken.jp/0004804I129S7SvEvBrdBALBcNODPrf1tm1ClrkPrf1tm1ClrkTgINSIl10Sar0Prf1tm1ClrkTgINSIl10Sar

decreased susceptibility to autoimmune diabetes_Prf1<tm1Clrk>/Prf1<tm1Clrk>,Tg(INS-Il10)#Sar/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• perforin 1 (pore forming protein)
  http://metadb.riken.jp/db/mgi_rdf/MGI:97551
• transgene insertion #, Nora Sarvetnick
  http://metadb.riken.jp/db/mgi_rdf/MGI:3622648

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Prf1<tm1Clrk>/Prf1<tm1Clrk>,Tg(INS-Il10)#Sar/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Prf1<tm1Clrk>|Tg(INS-Il10)#Sar

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * BALB/c * NOD

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased susceptibility to autoimmune diabetes
  http://purl.obolibrary.org/obo/MP_0004804

文献

http://purl.org/net/cito/citesAsAuthority

• B. Balasa, et.al., Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules., Journal of immunology (Baltimore, Md. : 1950), 2000, 165
  http://rdf.ncbi.nlm.nih.gov/pubmed/10946317