decreased hematopoietic stem cell number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>

http://metadb.riken.jp/0004810I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliTrp53tm1BrnTrp53tm1BrnGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26SorTrp53tm1BrnBcl11atm21PeliGtROSA26Sortm2creERT2Brn

decreased hematopoietic stem cell number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• B cell CLL/lymphoma 11A (zinc finger protein)
  http://metadb.riken.jp/db/mgi_rdf/MGI:106190
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Trp53<tm1Brn>|Bcl11a<tm2.1Peli>|Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased hematopoietic stem cell number
  http://purl.obolibrary.org/obo/MP_0004810

文献

http://purl.org/net/cito/citesAsAuthority

• Yong. Yu, et.al., Bcl11a is essential for lymphoid development and negatively regulates p53., The Journal of experimental medicine, 2012, 209
  http://rdf.ncbi.nlm.nih.gov/pubmed/23230003