decreased hematopoietic stem cell number_Etv6<tm1(RUNX1)Haho>/Etv6<+>,Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0004810I129S1Sv129S4SvJaeC57BL6CBAEtv6tm1RUNX1HahoEtv6Runx1tm3SpeRunx1tm3SpeTgMx1cre1Cgn0Etv6Runx1tm3SpeTgMx1cre1CgnEtv6tm1RUNX1Haho

decreased hematopoietic stem cell number_Etv6<tm1(RUNX1)Haho>/Etv6<+>,Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• ets variant 6
  http://metadb.riken.jp/db/mgi_rdf/MGI:109336
• runt related transcription factor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:99852
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Etv6<tm1(RUNX1)Haho>/Etv6<+>,Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Etv6<+>|Runx1<tm3Spe>|Tg(Mx1-cre)1Cgn|Etv6<tm1(RUNX1)Haho>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased hematopoietic stem cell number
  http://purl.obolibrary.org/obo/MP_0004810

文献

http://purl.org/net/cito/citesAsAuthority

• Jeffrey W. Schindler, et.al., TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia., Cell stem cell, 2009, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/19570513